Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations.

@article{Lee2000ImportanceOR,
  title={Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations.},
  author={Mei-Ling Ting Lee and Frank C. Kuo and George Alex Whitmore and Jeffrey Sklar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 18},
  pages={9834-9}
}
We present statistical methods for analyzing replicated cDNA microarray expression data and report the results of a controlled experiment. The study was conducted to investigate inherent variability in gene expression data and the extent to which replication in an experiment produces more consistent and reliable findings. We introduce a statistical model to describe the probability that mRNA is contained in the target sample tissue, converted to probe, and ultimately detected on the slide. We… CONTINUE READING
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Misclassification percentages for different combinations of replicates Classification Outcome Combination of Replicates

  • M. B. Eisen, P. T. Spellman, P. O. Brown, D. Bostein
  • Proc. Natl. Acad. Sci. USA
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