Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.


For the optimization of dosing regimens of anti-infective agents, it is imperative to have a good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever possible, drug efficacy needs to be related to unbound concentrations at the site of action. For anti-infective drugs, the infection site is typically located outside plasma, and a drug… (More)
DOI: 10.1128/CMR.00092-12