Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors.

Abstract

Hormonal or dietary challenge can stimulate hepatic low-density lipoprotein receptor (LDLR) expression through posttranscriptional mechanisms. We here tested whether such observations may be due to regulation of proprotein convertase subtilisin/kexin type 9 (PCSK9). Treatment with glucagon resulted in a 2-fold increase in hepatic LDLR protein expression… (More)
DOI: 10.1210/en.2008-1281

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@article{Persson2009ImportanceOP, title={Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors.}, author={Lena Persson and Cecilia G{\"a}lman and B O Angelin and Mats Rudling}, journal={Endocrinology}, year={2009}, volume={150 3}, pages={1140-6} }