Importance of phosphoenolpyruvate carboxylase of Corynebacterium glutamicum during the temperature triggered glutamic acid fermentation.

@article{Delaunay1999ImportanceOP,
  title={Importance of phosphoenolpyruvate carboxylase of Corynebacterium glutamicum during the temperature triggered glutamic acid fermentation.},
  author={St{\'e}phane Delaunay and Davin Uy and Marie- France Baucher and Jean Marc Engasser and Armel Guyonvarch and Jean Louis Goergen},
  journal={Metabolic engineering},
  year={1999},
  volume={1 4},
  pages={334-43}
}
To give clues about the respective importance of phosphoenol-pyruvate carboxylase (PEPc) and pyruvate carboxylase (Pc) in Corynebacterium glutamicum metabolism during a temperature triggered glutamic acid fermentation, PEPc activity was genetically amplified and Pc activity was suppressed by biotin limitation in the culture medium. In absence of Pc activity, glutamate production was dramatically reduced whereas lactate excretion was strongly increased. Whereas PEPc amplification in excess of… CONTINUE READING

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