Importance of mevalonate‐derived products in the control of HMG‐CoA reductase activity and growth of human lung adenocarcinoma cell line a549

@article{Bennis1993ImportanceOM,
  title={Importance of mevalonate‐derived products in the control of HMG‐CoA reductase activity and growth of human lung adenocarcinoma cell line a549},
  author={Fa{\"i}za Bennis and Gilles Favre and Francis Le Gaillard and Georges Soula},
  journal={International Journal of Cancer},
  year={1993},
  volume={55}
}
HMG‐CoA reductase catalyzes the synthesis of mevalonate, a crucial intermediate in the biosynthesis of cholesterol and non‐sterol isoprenoid compounds essential for cell growth. The HMG‐CoA reductase activity of the A549 tumor cell line is higher than that of normal human fibroblasts. This deregulation in mevalonate needs was not due to an alteration in the activated state of the enzyme by short‐term regulation. We show that the HMG‐CoA reductase in A549 cell line was subject to a multivalent… 
Dietary factors and the regulation of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase: Implications for breast cancer development
TLDR
Evidence suggesting that inhibition of mevalonate synthesis may mediate the protective effects of cholesterol, plant isoprenoids, genistein, and long-chain n-3 polyunsaturated fatty acids (PUFAs) on experimental breast cancer is reviewed.
Regulation of the Mevalonate Pathway for the Prevention of Breast Cancer
TLDR
It was shown that exogenous mevalonate promotes growth of breast cancer cells in nude mice as well as proliferation of the cells in culture and these findings may be important since common treatments to lower serum cholesterol increase meValonate synthesis.
The structure of the catalytic portion of human HMG-CoA reductase.
TLDR
Catalytic portions of human HMGR form tight tetramers, explaining the influence of the enzyme's oligomeric state on the activity and suggesting a mechanism for cholesterol sensing.
Reversion of transformed phenotype of human adenocarcinoma A549 cells by expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase complementary DNA.
TLDR
The data together strongly suggest that phenotype reversion is dependent on exogenous HMG-CoA reductase expression and that enzymatic activity is implied in this mechanism.
Crystal structure of the catalytic portion of human HMG‐CoA reductase: insights into regulation of activity and catalysis
TLDR
The crystal structure of the catalytic portion of human HMGR explains the influence of the enzyme's oligomeric state on the activity and suggests a mechanism for cholesterol sensing.
Isoprenoid-Mediated Inhibition of Mevalonate Synthesis: Potential Application to Cancer
TLDR
The combined actions of the estimated 23,000 isoprenoid constituents of plant materials, acting in concert with other chemopreventive phytochemicals, may explain the lowered cancer risk associated with a diet rich in plant products.
Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer.
TLDR
The combined actions of the estimated 23,000 isoprenoid constituents of plant materials, acting in concert with other chemopreventive phytochemicals, may explain the lowered cancer risk associated with a diet rich in plant products.
Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer.
TLDR
The cholesterol pathway is involved in colon malignant transformation and therapeutic strategies using HMGCoA reductase inhibitors as anti-cancer compounds should also take into consideration the biological and clinical differences detected inside colon tracts.
Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.
  • M. Polo, M. D. de Bravo
  • Biology, Medicine
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2006
TLDR
Geraniol has multiple effects on mevalonate and lipid metabolism in Hep G2 cells, affecting cell proliferation and cholesterogenesis, protein prenylation, and fatty-acid metabolism.
Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: Effect on HMG‐CoA reductase activity
TLDR
This is one of the first reports demonstrating that saturated and n‐3 PUFA only show differential effects on HMG‐CoA reductase activity in the presence of lipoproteins.
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