Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.

@article{Oupick2002ImportanceOL,
  title={Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.},
  author={David Oupick{\'y} and Manfred Ogris and Kenneth A Howard and Philip R Dash and Karel Ulbrich and Leonard W Seymour},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2002},
  volume={5 4},
  pages={463-72}
}
Gene therapy for systemic diseases requires intravenous administration, but existing vectors are not suitable for systemic delivery, often showing rapid elimination from the bloodstream that restricts potential transfection sites to "first-pass" organs. To develop long-circulating vectors, here we have compared polyplexes containing DNA and poly-L-lysine (PLL) or polyethylenimine (PEI), surface-modified with either monovalent polyethylene glycol (PEG) or multivalent copolymers of N-(2… CONTINUE READING
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