Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials.

@article{Kjekshus1986ImportanceOH,
  title={Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials.},
  author={John K. Kjekshus},
  journal={The American journal of cardiology},
  year={1986},
  volume={57 12},
  pages={43F-49F}
}
Heart rate after an acute myocardial infarction (AMI) is an index of late mortality. The hypothesis--that the potential beneficial effect of beta-blocking drugs after an AMI is quantitatively dependent on the reduction of heart rate obtained by such treatment--was examined by reviewing available data from acute and long-term intervention trials. Only properly randomized and double-blind trials were considered. In acute intervention trials only patients who received treatment within 12 hours… CONTINUE READING