Importance of geometry of the extracellular matrix in endochondral bone differentiation

@article{Sampath1984ImportanceOG,
  title={Importance of geometry of the extracellular matrix in endochondral bone differentiation},
  author={T. Kuber Sampath and A. Hari Reddi},
  journal={The Journal of Cell Biology},
  year={1984},
  volume={98},
  pages={2192 - 2197}
}
Subcutaneous implantation of coarse powders (74-420 micron) of demineralized diaphyseal bone matrix resulted in the local differentiation of endochondral bone. However, implantation of matrix with particle size of 44-74 micron (Fine matrix) did not induce bone. We have recently reported that the dissociative extraction of coarse matrix with 4 M guanidine HCl resulted in a complete loss of the ability of matrix to induce endochondral bone; the total loss of biological activity could be restored… CONTINUE READING
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