Importance of functional EGF receptors in recovery from acute nephrotoxic injury.

@article{Wang2003ImportanceOF,
  title={Importance of functional EGF receptors in recovery from acute nephrotoxic injury.},
  author={Zoufei Wang and Jian-kang Chen and Su-wan Wang and Gilbert Moeckel and Raymond C Harris},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 12},
  pages={3147-54}
}
Previous studies have demonstrated increased renal expression of EGF receptor (EGFR) and EGFR ligands in response to acute toxic or ischemic renal tubular injury and have indicated that exogenous administration of EGF accelerates recovery from such injury. However, no studies to date have proved definitively an essential role for EGFR-mediated responses in regeneration after tubule injury. To this end, waved-2 (wa-2) mice, which contain a point mutation in EGFR that reduces receptor tyrosine… CONTINUE READING

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