Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

@article{Falet2002ImportanceOF,
  title={Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.},
  author={Herv{\'e} Falet and Karin M Hoffmeister and Ralph Neujahr and Joseph E. Italiano and ThomasP. Stossel and Frederick Seacrest Southwick and John H. Hartwig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 26},
  pages={
          16782-7
        }
}
We investigated the effect of actin filament barbed end uncapping on Arp23 complex function both in vivo and in vitro. Arp23 complex redistributes rapidly and uniformly to the lamellar edge of activated wild-type platelets and fibroblasts but clusters in marginal actin filament clumps in gelsolin-null cells. Treatment of gelsolin-null platelets with the negative dominant N-WASp C-terminal CA domain has no effect on their residual actin nucleation activity, placing gelsolin actin filament… CONTINUE READING
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