Importance of fixation in immunohistochemistry: use of formaldehyde solutions at variable pH for the localization of tyrosine hydroxylase.

@article{Brod1981ImportanceOF,
  title={Importance of fixation in immunohistochemistry: use of formaldehyde solutions at variable pH for the localization of tyrosine hydroxylase.},
  author={Anne B{\'e}rod and Boyd K. Hartman and J F Pujol},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1981},
  volume={29 7},
  pages={844-50}
}
Adequate fixative in immunohistochemistry requires not only a rapid and total immobilization of the antigen, but also a sufficient preservation of its immunoreactivity and maintenance of its accessibility to the immunochemical reagents for localization. Thus, the optimal fixation condition for a specific antigen necessitates a compromise between these opposing variables and can be determined by the preparation of a series of tissues with a progressively increasing degree of fixation. Unless the… CONTINUE READING
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