Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation.

@article{Saito2013ImportanceOE,
  title={Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation.},
  author={Tokuo Saito and Yutaka Hasegawa and Yasushi Ishigaki and Tetsuya Yamada and Junhong Gao and Junta Imai and Kenji Uno and Keizo Kaneko and Takehide Ogihara and Tatsuo Shimosawa and Tomoichiro Asano and Toshiro Fujita and Yoshitomo Oka and Hideki Katagiri},
  journal={Cardiovascular research},
  year={2013},
  volume={97 1},
  pages={106-14}
}
AIMS Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB) regulates the expressions of numerous genes, including those related to pro-inflammatory responses. Therefore, to investigate the roles of endothelial pro-inflammatory responses… CONTINUE READING
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