Importance of dose of type II collagen in suppression of collagen-induced arthritis by nasal tolerance.


OBJECTIVE To determine the influence of the dose of collagen given nasally on the induction of specific mucosal tolerance in collagen-induced arthritis. METHODS The severity of clinical arthritis induced in DBA/1 mice was studied after the nasal administration (before disease induction) of 1 of 4 doses (across a 2-log range) of bovine type II collagen… (More)


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