Importance of direct macrophage-tumor cell interaction on progression of human glioma.

@article{Komohara2012ImportanceOD,
  title={Importance of direct macrophage-tumor cell interaction on progression of human glioma.},
  author={Yoshihiro Komohara and Hasita Horlad and Koji Ohnishi and Yukio Fujiwara and Bing Bai and Takenobu Nakagawa and Shinya Suzu and Hideo Nakamura and Jun-ichi Kuratsu and Motohiro Takeya},
  journal={Cancer science},
  year={2012},
  volume={103 12},
  pages={2165-72}
}
We previously showed tumor-associated macrophages/microglia (TAMs) polarized to the M2 phenotype were significantly involved in tumor cell proliferation and poor clinical prognosis in patients with high grade gliomas. However, the detailed molecular mechanisms involved in the interaction between TAMs and tumor cells have been unclear. Current results reveal that, in coculture with human macrophages, BrdU incorporation was significantly elevated in glioma cells, and signal transducer and… CONTINUE READING

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Macrophage plasticity and polarization: in vivo veritas

A Sica, A. Mantovani
J Clin Invest • 2012

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