Importance of direct macrophage ‐ Tumor cell interaction on progression of human glioma

  title={Importance of direct macrophage ‐ Tumor cell interaction on progression of human glioma},
  author={Y. Komohara and Hasita Horlad and K. Ohnishi and Yukio Fujiwara and B. Bai and Takenobu Nakagawa and S. Suzu and H. Nakamura and J. Kuratsu and M. Takeya},
  journal={Cancer Science},
  pages={2165 - 2172}
  • Y. Komohara, Hasita Horlad, +7 authors M. Takeya
  • Published 2012
  • Biology, Medicine
  • Cancer Science
  • We previously showed tumor‐associated macrophages/microglia (TAMs) polarized to the M2 phenotype were significantly involved in tumor cell proliferation and poor clinical prognosis in patients with high grade gliomas. However, the detailed molecular mechanisms involved in the interaction between TAMs and tumor cells have been unclear. Current results reveal that, in coculture with human macrophages, BrdU incorporation was significantly elevated in glioma cells, and signal transducer and… CONTINUE READING
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