Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.

@article{Holliday2007ImportanceOC,
  title={Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.},
  author={Nicholas D. Holliday and Birgitte Holst and Elena A. Rodionova and Thue W. Schwartz and Helen M Cox},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 12},
  pages={3100-12}
}
The ghrelin receptor (GhrelinR) and its related orphan GPR39 each display constitutive signaling, but only GhrelinRs undergo basal internalization. Here we investigate these differences by considering the roles of the C tail receptor domains for constitutive internalization and activity. Furthermore the interaction between phosphorylated receptors and beta-arrestin adaptor proteins has been examined. Replacement of the FLAG-tagged GhrelinR C tail with the equivalent GPR39 domain (GhR-39 chimera… CONTINUE READING