Importance of codon usage for the temporal regulation of viral gene expression.

  title={Importance of codon usage for the temporal regulation of viral gene expression.},
  author={Young C Shin and Georg F Bischof and William A Lauer and Ronald C Desrosiers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 45},
The glycoproteins of herpesviruses and of HIV/SIV are made late in the replication cycle and are derived from transcripts that use an unusual codon usage that is quite different from that of the host cell. Here we show that the actions of natural transinducers from these two different families of persistent viruses (Rev of SIV and ORF57 of the rhesus monkey rhadinovirus) are dependent on the nature of the skewed codon usage. In fact, the transinducibility of expression of these glycoproteins by… CONTINUE READING
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