Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.


B cell immunotherapy has emerged as a mainstay in the treatment of lymphomas and autoimmune diseases. Although the microenvironment has recently been demonstrated to play critical roles in B cell homeostasis, its contribution to immunotherapy is unknown. To analyze the in vivo factors that regulate mechanisms involved in B cell immunotherapy, we used a murine model for human CD20 (hCD20) expression in which treatment of hCD20(+) mice with anti-hCD20 mAbs mimics B cell depletion observed in humans. We demonstrate in this study that factors derived from the microenvironment, including signals from the B cell-activating factor belonging to the TNF family/BLyS survival factor, integrin-regulated homeostasis, and circulatory dynamics of B cells define distinct in vivo mechanism(s) and sensitivities of cells in anti-hCD20 mAb-directed therapies. These findings provide new insights into the mechanisms of immunotherapy and define new opportunities in the treatment of cancers and autoimmune diseases.

7 Figures and Tables

Citations per Year

2,073 Citations

Semantic Scholar estimates that this publication has 2,073 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gong2005ImportanceOC, title={Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.}, author={Qian Gong and Qinglin Ou and Shiming Ye and Wyne P Lee and Jennine Cornelius and Lauri J Diehl and Lea Weinisch and Zhilan Hu and Yanmei Lu and Yongmei Chen and Yan Wu and Yu-Ju Gloria Meng and Peter Gribling and Zhonghua Lin and Kathy Dang Nguyen and Thanhvien Tran and Yifan Zhang and Hugh Rosen and Flavius Martin and Andrew Chan}, journal={Journal of immunology}, year={2005}, volume={174 2}, pages={817-26} }