Importance of beta-lactamase induction

@article{Phillips2006ImportanceOB,
  title={Importance of beta-lactamase induction},
  author={Ian Phillips and Kevin P. Shannon},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={2006},
  volume={12},
  pages={S19-S26}
}
  • I. Phillips, K. Shannon
  • Published 2006
  • Biology, Medicine
  • European Journal of Clinical Microbiology and Infectious Diseases
Induction of an enzyme is a temporary phenomenon in which the rate of enzyme synthesis is greatly increased in response to the presence of an inducer in the environment. Induction of β-lactamase synthesis is important for the resistance of staphylococci to penicillins since the drug both induces synthesis of the enzyme and is hydrolysed by it. Similarly, some compounds both strongly induce and are hydrolysed by the chromosomally-determined β-lactamases of gram-negative bacilli (e.g. amoxicillin… 

Figures and Tables from this paper

In vitro expression of beta-lactam-induced response by clinical gram-negative bacteria with the potential for inducible beta-lactamase production.
TLDR
The test presented here may be well-suited to studying inducibility of beta-lactamase production in the diagnostic laboratory, and an explanation to be proposed for the multi(-beta- lactam)-resistance.
Induction of beta-lactamase by cefoxitin in anaerobic intestinal microflora
TLDR
The results of the present study indicate that increased levels of beta-lactamases in the normal intestinal microflora are probably due to selection of stably derepressed mutants rather than to induction of Beta- lactamase production.
Behaviour against β-lactams in Aeromonas spp. isolated from extraintestinal infections
TLDR
The results support the hypotheses that it is possible that the therapeutic failures of s-lactams in the treatment of infections caused by Aeromonas spp.
Extended-Spectrum β-Lactamase Enzymes (ESBLs) Produced by Escherichia coli Urinary Pathogens at Riyadh, Saudi Arabia
TLDR
This study showed that the ESBL producing isolates detected PCR with oligonucleotide primers of TEM, SHV, and CTX-M and OXA genes and were carried out on E. coli DNA of 75 isolates, indicating that PCR, incorporating the primers for commonly prevalent ESBLs may be a valuable clinical and research tool for characterization of ES BLs.
Physiological and molecular responses of antibiotic- resistant Salmonella enterica serovar Typhimurium to acid stress
TLDR
The results suggest that the antibiotic resistance property of S. Typhimurium under mild acidic condition were highly associated with lactamase activity, efflux pump activity, and cell surface protein profiles, suggesting that the hyperproduction of β-lactamases regardless of antibiotic resistance.
Aeromonas spp. involucradas en infecciones extraintestinales diagnosticadas en centros de salud de posadas, Misiones
TLDR
The hypotheses that it would be possible that the resistance acquired in Aeromonas spp.
Non-canonical mechanisms of antibiotic resistance
TLDR
The present article reviews some of these mechanisms which are grouped under the term ‘non-canonical mechanisms’ of antibiotic resistance, which include gene dosage, heterologous induction or selection, populational resistance and synergism between mechanisms of low resistance.
Controlling Antibiotic Resistance: Strategies Based on the Mutant Selection Window
TLDR
It is argued that eliminating misuse will fail to correct the resistance problem fully because traditional dosing strategies keep us only one mutational step ahead of the pathogens, and it may be necessary to change the paradigm used to establish dosing regimens.
Biodegradation of Pharmaceutical Wastes in Treated Sewage Effluents by Bacillus subtilis 1556WTNC
TLDR
It can be concluded that B. subtilis 1556WTNC is suitable to remove pharmaceutical residues from the treated sewage effluent and produce effluents at higher quality than that achieved by secondary treatment process.
...
1
2
...

References

SHOWING 1-10 OF 24 REFERENCES
Induction Kinetics of β-Lactamase Biosynthesis in Pseudomonas aeruginosa
TLDR
The induction of β-lactamase in Pseudomonas aeruginosa 1822s was studied using benzylpenicillin as inducer and the basal and the induced enzymes seem to be identical since they had the same substrate profile, electrophoretic mobility, and molecular weight.
The effects on ß-lactam susceptibility of phenotypic induction and genotypic derepression of ß-lactamase synthesis
TLDR
Imipenem was compared with cefotaxime and cefoxitin as an agent for the selection of beta-lactam-resistant variants and failed to antagonize the activity of other compounds, even when present concurrently with them.
Type I beta-lactamases of gram-negative bacteria: interactions with beta-lactam antibiotics.
TLDR
The activity of the penems, penams, and carbapenems was least affected by derepression of beta-lactamase, whereas the activity of anionic cephalosporins and aztreonam was most affected.
Ability of newer beta-lactam antibiotics to induce beta-lactamase production inEnterobacter cloacae
  • R. Then
  • Biology, Medicine
    European Journal of Clinical Microbiology
  • 2005
TLDR
The beta-lactamase inducing properties of various new beta- lactam antibiotics in two isogenic strains ofEnterobacter cloacae were investigated, with highest levels being obtained after induction with cefoxitin in Tryptic Soy broth, Mueller-Hinton broth and Nutrient broth.
Antibacterial activity, penicillinase stability and inducing ability of different penicillins.
TLDR
Of the penicillins used methicillin is by far the best inducer-but it is uncertain how much this is due to a true ‘inducing affinity’ and how much a result of its resistance to hydrolysis.
Clavnlanate and β-lactamase induction
TLDR
It appears that beta-lactamase induction is unlikely to cause significant antagonism, and clavulanate-induced enzyme inactivates ticarcillin, which itself is a feeble inducer.
Inducible Type I βlactamases of Gram-negative bacteria and resistance to βlactam antibiotics
Mutants, showing either constitutive (depressed) or non-inducible expression of chromosomally-mediated Type I beta-lactamase were obtained from clinical isolates of Enterobacter cloacae, Ent.
A comparison of aztreonam and imipenem induction of class I beta-lactamase in Enterobacter cloacae ATCC 13047.
TLDR
It is proposed that the phenomena of an optimum inducing concentration and the interference with the assay of beta-lactamase by the presence of residual antibiotic demonstrated in this study with aztreonam and imipenem would be of relevance when applied more broadly to studies of Beta-lacticamase induction.
Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae.
TLDR
Among the tested cephalosporins, cephamycin derivatives such as cefoxitin, cefmetazole, and YM09330 had high inducer activity even at low drug concentrations, while cefoperazone,cefsulodin, piperacillin, and apalcillin showed low inducers activity when compared with the other cep Halosporin derivatives.
INDUCTION OF STAPHYLOCOCCAL PENICILLINASE
TLDR
Results support the hypothesis that staphylococcal penicillinase is an inducible enzyme with properties similar to that of B. cereus.
...
1
2
3
...