Importance of beta(2)adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics.

@article{Lima2000ImportanceOB,
  title={Importance of beta(2)adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics.},
  author={J. J. G. Lima and Mahmoud Hassan Mohamed and Timothy H Self and Lukas Eberle and Julie A. Johnson},
  journal={Pulmonary pharmacology & therapeutics},
  year={2000},
  volume={13 3},
  pages={127-34}
}
To determine whether race and gender affect beta(2)receptor-stimulated bronchodilation, we quantified FEV(1)and plasma concentrations of albuterol at various times following the oral administration of a single 8-mg dose of albuterol in 15 black and 15 white male and female asthmatics. No important racial or gender differences in albuterol-evoked FEV(1)or percent-predicted FEV(1)were evident, although females tended to be more sensitive compared to males. Pharmacodynamic (PD) models were fitted… CONTINUE READING