Importance of basic residues and quaternary structure in the function of MIP-1 beta: CCR5 binding and cell surface sugar interactions.

@article{Laurence2001ImportanceOB,
  title={Importance of basic residues and quaternary structure in the function of MIP-1 beta: CCR5 binding and cell surface sugar interactions.},
  author={Jennifer S. Laurence and C{\'e}dric Blanpain and Anne de Leener and Marc Parmentier and Patricia LiWang},
  journal={Biochemistry},
  year={2001},
  volume={40 16},
  pages={
          4990-9
        }
}
Chemokines direct immune cells toward sites of infection by establishing a gradient across the extracellular matrix of the tissue. This gradient is thought to be stabilized by ligation of chemokines to sulfated polysaccharides known as glycosaminoglycans (GAGs) that are found on the surface of endothelial and other cells as well as in the tissue matrix. GAGs interact with chemokines and in some cases cause them to aggregate. The interaction between cell surface GAGs and chemokines has also been… CONTINUE READING

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