Importance of bacillithiol in the oxidative stress response of Staphylococcus aureus.

@article{Posada2014ImportanceOB,
  title={Importance of bacillithiol in the oxidative stress response of Staphylococcus aureus.},
  author={Ana C Posada and Stacey L. Kolar and Renata G Dusi and Patrice François and Alexandra A Roberts and Chris J. Hamilton and George Y. Liu and Ambrose L. Cheung},
  journal={Infection and immunity},
  year={2014},
  volume={82 1},
  pages={316-32}
}
In Staphylococcus aureus, the low-molecular-weight thiol called bacillithiol (BSH), together with cognate S-transferases, is believed to be the counterpart to the glutathione system of other organisms. To explore the physiological role of BSH in S. aureus, we constructed mutants with the deletion of bshA (sa1291), which encodes the glycosyltransferase that catalyzes the first step of BSH biosynthesis, and fosB (sa2124), which encodes a BSH-S-transferase that confers fosfomycin resistance, in… CONTINUE READING
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