Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer.

@article{Bureau2000ImportanceOA,
  title={Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer.},
  author={Michel Francis Bureau and Julie Gehl and Virginie Deleuze and Lluis M. Mir and Daniel Scherman},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1474 3},
  pages={353-9}
}
Gene transfer using electrical pulses is a rapidly expanding field. Many studies have been performed in vitro to elucidate the mechanism of DNA electrotransfer. In vivo, the use of efficient procedures for DNA electrotransfer in tissues is recent, and the question of the implied mechanisms is largely open. We have evaluated the effects of various combinations of square wave electric pulses of variable field strength and duration, on cell permeabilization and on DNA transfection in the skeletal… CONTINUE READING

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