Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing Peptide receptor for phospholipase C activation, internalization, and chronic down-regulation.

@article{Schumann2003ImportanceOA,
  title={Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing Peptide receptor for phospholipase C activation, internalization, and chronic down-regulation.},
  author={Michael Schumann and Tomoo Nakagawa and Samuel A. Mantey and Kenji Tokita and David J Venzon and Simon J. Hocart and Richard V. Benya and Robert Thomas Jensen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 2},
  pages={
          597-607
        }
}
Little is known about the function of the central portion of the second intracellular loop (i2 loop) of peptide receptors in activation of downstream pathways and receptor modulatory processes such as receptor internalization or chronic down-regulation (DR). Recent data suggest a role for i2 loop hydrophobic amino acids in these processes. We used site-directed mutagenesis to address these issues with the gastrin-releasing peptide receptor (GRP-R). Each i2 loop residue from 142 to 148 was… CONTINUE READING

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