Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury.

@article{MartnezChantar2002ImportanceOA,
  title={Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury.},
  author={Mar{\'i}a L. Mart{\'i}nez-Chantar and Elena Ruiz Garc{\'i}a-Trevijano and Mar{\'i}a Ujue Latasa and Isabel P{\'e}rez-Mato and Manuel M S{\'a}nchez Del Pino and Fernando Jos{\'e} Corrales and Mat{\'i}as A. Avila and Jose M. Mato},
  journal={The American journal of clinical nutrition},
  year={2002},
  volume={76 5},
  pages={1177S-82S}
}
One of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with that in control subjects. Almost 15 y ago we observed that the failure to metabolize methionine in cirrhosis was due to an abnormally low activity of the enzyme methionine adenosyltransferase (EC 2… CONTINUE READING