Importance of Water Content of the Stratum Corneum in Mouse Models for Contact Hypersensitivity.

  title={Importance of Water Content of the Stratum Corneum in Mouse Models for Contact Hypersensitivity.},
  author={Takaaki Doi and Yoshiko Mizukawa and Yurie Shimoda and Yoshimi Yamazaki and Tetsuo Shiohara},
  journal={The Journal of investigative dermatology},
  volume={137 1},
Although a marked rise in the prevalence of allergic diseases over the past few decades may be related to environmental factors in industrialized countries, evidence for the protective effect of humidity on the barrier function of the skin is still awaited. We asked whether an increase in the water content of stratum corneum at the site of hapten application had a strong impact on the magnitude of contact hypersensitivity (CHS). The magnitude of CHS, induced by either lipid-soluble or water… CONTINUE READING

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