Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses*

@inproceedings{Verpelli2011ImportanceOS,
  title={Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses*},
  author={Chiara Verpelli and Elena Dvoretskova and Cinzia Vicidomini and Francesca Rossi and Michela Chiappalone and Michael P Sch{\"o}n and Bruno Di Stefano and Renato Mantegazza and Vania Broccoli and Tobias Maria Boeckers and Alexander Dityatev and Carlo Sala},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. We have used RNAi to knockdown Shank3 expression in neuronal cultures and showed that this treatment specifically reduced the synaptic expression of the metabotropic glutamate receptor 5 (mGluR5), but did… CONTINUE READING