Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis.

  title={Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis.},
  author={Hung-Che Chien and Pei-Chi Chan and Chuan‐Chou Tu and Yuan-Ji Day and Li-man Hung and Chi-Chang Juan and Yu-Feng Tian and Po-Shiuan Hsieh},
  journal={The Chinese journal of physiology},
  volume={61 5},
Regulated upon activation, normal T cell expressed, and secreted (RANTES), also known as chemokine ligand 5 (CCL5), has been reported to facilitate macrophage migration, which plays a crucial role in tissue inflammation. The aim of this study is to investigate the characteristics and underlying mechanism of RANTES on macrophage chemotaxis under physiological and pathological conditions. The study was conducted on macrophage RAW264.7 cell and bone marrow-derived macrophages (BMDM) isolated from… 

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