Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis.

@article{Chien2018ImportanceOP,
  title={Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis.},
  author={Hung-Che Chien and Pei-Chi Chan and Chuan‐Chou Tu and Yuan-Ji Day and Li-man Hung and Chi-Chang Juan and Yu-Feng Tian and Po-Shiuan Hsieh},
  journal={The Chinese journal of physiology},
  year={2018},
  volume={61 5},
  pages={
          266-279
        }
}
Regulated upon activation, normal T cell expressed, and secreted (RANTES), also known as chemokine ligand 5 (CCL5), has been reported to facilitate macrophage migration, which plays a crucial role in tissue inflammation. The aim of this study is to investigate the characteristics and underlying mechanism of RANTES on macrophage chemotaxis under physiological and pathological conditions. The study was conducted on macrophage RAW264.7 cell and bone marrow-derived macrophages (BMDM) isolated from… 

Figures from this paper

CCL5/CCR5 axis in human diseases and related treatments

Supernatants From Human Osteosarcoma Cultured Cell Lines Induce Modifications in Growth and Differentiation of THP-1 Cells and Phosphoinositide- Specific Phospholipase C Enzymes

The effects of tumor environment on monocyte-macrophage cell lineage is identified by evaluating morphological and functional changes in THP-1 cells cultured in culture medium mixed with the culture supernatant of one of three different osteosarcoma cell lines.

Adipose Tissue-Derived CCL5 Enhances Local Pro-Inflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice

It is suggested that an obesity-induced increase in adipose tissue CCL5-mediated signaling is crucial in the recruitment of tissue M-MDSCs and their trans-differentiation to tissue pro-inflammatory macrophages, resulting in adipOSE tissue inflammation and insulin resistance.

Co-receptor signaling in the pathogenesis of neuroHIV

This discussion will provide a comprehensive overview of what is known and what remains to be explored in regard to co-receptor signaling and HIV infection, and will emphasize the potential value of HIV co- receptors as a target for future therapeutic development.

Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach

Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model

It is demonstrated that Maraviroc, a drug approved for human use, reduces the liver stem cell response and macrophage activation in a mouse model of liver cancer, suggesting it has potential as a cancer therapeutic.

PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation

Data suggest PPARδ, and FOXO1 transcription factors increased PDK4 protein in the presence of palmitate, which limited PDC activity and flux, and blunted CHO oxidation and glucose uptake, and EPS rescued these metabolic events by modulating the same transcription factors.

The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity

An update on the link between chemokines and obesity-related inflammation and metabolism dysregulation under the light of recent knowledge is presented, which may present important therapeutic targets that could control obesity-associated immune and metabolic disorders and chronic complications in the near future.

Inhibitory Effect of Rhododendron Mucronulatum Root Extract on Allergic Inflammation

It is concluded that RME possesses anti-allergic activity and anti-inflammatory activity due to the inhibition of mast cells and macrophage function.

References

SHOWING 1-10 OF 42 REFERENCES

CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways.

The Chemokine CCL5 Regulates Glucose Uptake and AMP Kinase Signaling in Activated T Cells to Facilitate Chemotaxis*

It is suggested that both glycolysis and AMPK signaling are required for efficient T cell migration in response to CCL5, and a role for chemokines in promoting glucose uptake and ATP production to match energy demands of migration is described.

RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA.

It is shown that RantES stimulates dose-dependent phospholipase D (PLD) activity in Jurkat cells, indicating the potential existence of a novel receptor-mediated mechanism for activation of T cells by the chemokine RANTES.

Amelioration of rat adjuvant-induced arthritis by Met-RANTES.

The data suggest that the targeting of Th1-associated chemokine receptors reduce joint inflammation, bone destruction, and cell recruitment into joints with AIA.

Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4.

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue

CCL5 could participate in the inflammation of obese WAT by recruiting blood monocytes and exerting antiapoptotic properties on WAT macrophages and should be taken into account for future therapeutic strategies in obesity-related diseases.

Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue

It is found that insulin stimulates THP-1 cell chemotaxis in a dose-dependent and insulin receptor-dependent manner and the kinases PI3K-Akt, SPAK/JNK, and p38 MAPK are key molecules in the insulin-induced signaling pathways that lead to chemoattraction of the THP/macrophage cell.

C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.

Propagermanium improved diet-induced obesity and related metabolic disorders, such as insulin resistance and hepatic steatosis, and that propagermanium may be a beneficial drug for the treatment of metabolic syndrome.

T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity

Obesity is associated with increased accumulation of T cells and macrophages in AT, which may play important roles in obesity-related disease by influencing preadipocytes/adipocyte functions.

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

It is shown that mice lacking the chemokine Ccl5 are immune compromised to the point of delayed viral clearance, excessive airway inflammation and respiratory death after mouse parainfluenza or human influenza virus infection.