Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.

@article{Grnlien2010ImportanceOM,
  title={Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.},
  author={Jens Halvard Gr\onlien and Hilde Ween and Kirsten K Thorin-Hagene and Steven Cassar and Jinhe Li and Clark Briggs and Murali M Gopalakrishnan and John Malysz},
  journal={European journal of pharmacology},
  year={2010},
  volume={647 1-3},
  pages={37-47}
}
Genistein and 5-hydroxyindole (5-HI) potentiate the α7 nicotinic acetylcholine receptor current by primarily increasing peak amplitude, a property of type I α7 positive allosteric modulation. In this study, the effects of these two compounds were investigated at two different α7/5-HT(3) chimeras (chimera 1, comprising of extracellular α7 N-terminus fused to the remainder of 5-HT(3A), and chimera 2 containing an additional α7 encoded M2-M3 loop), and wild-type α7 and 5-HT(3A) receptors. Agonist… CONTINUE READING
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Distinct pro fi les of alpha 7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

  • J. H. Gronlien, M. Hakerud, +4 authors J. Malysz
  • Mol . Pharmacol .
  • 2007
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