Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation.

@article{Coorens2015ImportanceOE,
  title={Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation.},
  author={Maarten Coorens and Albert van Dijk and Floris J Bikker and Edwin J A Veldhuizen and Henk P Haagsman},
  journal={Journal of immunology},
  year={2015},
  volume={195 8},
  pages={3970-7}
}
Cathelicidins are essential in the protection against invading pathogens through both their direct antimicrobial activity and their immunomodulatory functions. Although cathelicidins are known to modulate activation by several TLR ligands, little is known about their influence on DNA-induced macrophage activation. In this study, we explored the effects of cathelicidins on DNA-induced activation of chicken macrophages and elucidated the intracellular processes underlying these effects. Our… CONTINUE READING

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