Importance of DNA damage in the induction of apoptosis by ionizing radiation: effect of the scid mutation and DNA ploidy on the radiosensitivity of murine lymphoid cell lines.

@article{Radford1999ImportanceOD,
  title={Importance of DNA damage in the induction of apoptosis by ionizing radiation: effect of the scid mutation and DNA ploidy on the radiosensitivity of murine lymphoid cell lines.},
  author={Ian R. Radford and D. R. Jr. Aldridge},
  journal={International journal of radiation biology},
  year={1999},
  volume={75 2},
  pages={
          143-53
        }
}
PURPOSE To study the effects of the murine scid mutation and DNA ploidy on the susceptibility of lymphoid cell lines to induction of apoptosis by ionizing radiation and thereby to determine whether DNA lesions are critical initiators of apoptosis. MATERIALS AND METHODS Sensitivity to killing and rapidity of induction of apoptosis following y-irradiation or DNA-associated 125I decays were compared in pre-B and pre-T cell lines derived from wild-type mice and from mice homozygous or… CONTINUE READING
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