Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus.

@article{Johnson2003ImportanceOB,
  title={Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus.},
  author={Welkin E Johnson and Jeffrey D Lifson and Sabine M Lang and R Paul Johnson and Ronald C Desrosiers},
  journal={Journal of virology},
  year={2003},
  volume={77 1},
  pages={375-81}
}
The properties of three variants of cloned simian immunodeficiency virus strain 239 (SIV239) were compared. One strain (M5) lacked five sites for N-linked carbohydrate attachment in variable regions 1 and 2 (V1 and V2) of the gp120 envelope protein, one strain (DeltaV1-V2) completely lacked V1 and V2 sequences, and another (316) had nine mutations in the envelope that impart high replicative capacity for tissue macrophages. All three strains were capable of significant levels of fusion… CONTINUE READING

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