Import and metabolism of glutathione by Streptococcus mutans.

  title={Import and metabolism of glutathione by Streptococcus mutans.},
  author={C. David Sherrill and Robert Fahey},
  journal={Journal of bacteriology},
  volume={180 6},
Glutathione (gamma-GluCysGly, GSH) is not found in most gram-positive bacteria, but some appear to synthesize it and others, including Streptococcus mutans ATCC 33402, import it from their growth medium. Import of oxidized glutathione (GSSG) by S. mutans 33402 in 7H9 medium was shown to require glucose and to occur with an apparent Km of 18+/-5 microM. GSSG, GSH, S-methylglutathione, and homocysteine-glutathione mixed disulfide (hCySSG) were imported at comparable rates (measured by depletion… CONTINUE READING


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