Implications of using different cut-offs on symptom severity scales to define remission from depression.

@article{Zimmerman2004ImplicationsOU,
  title={Implications of using different cut-offs on symptom severity scales to define remission from depression.},
  author={Mark Zimmerman and Michael A Posternak and Iwona Chelminski},
  journal={International clinical psychopharmacology},
  year={2004},
  volume={19 4},
  pages={215-20}
}
A fundamental question in the medical management of disease is how well treatment works. Although there are many ways of defining improvement, one endpoint of definite interest is the resolution or remission of the disorder. In short-term antidepressant treatment trials, remission is usually defined according to post-treatment scores on symptom severity measures, such as the Hamilton Rating Scale for Depression (HRSD) or the Montgomery-Asberg Depression Rating Scale (MADRS). However, there is… CONTINUE READING