Implications of ubiquitin ligases in castration-resistant prostate cancer.

  title={Implications of ubiquitin ligases in castration-resistant prostate cancer.},
  author={Jianfei Qi and Lingling Fan and Arif Hussain},
  journal={Current opinion in oncology},
  volume={27 3},
PURPOSE OF REVIEW Significant advances have been made in the study of ubiquitination-mediated regulation of androgen receptor (AR). This review will highlight the latest developments in the mechanisms by which E3 ubiquitin ligases control AR activity, with implications in castration-resistant prostate cancer (CRPC). RECENT FINDINGS Several ubiquitin ligases have been identified to interact with and ubiquitinate AR, and consequently regulate the AR transcriptional programme. Different… CONTINUE READING
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