Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases.

@article{Ioannidis2006ImplicationsOS,
  title={Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases.},
  author={John P. A. Ioannidis and Thomas A. Trikalinos and Muin J. Khoury},
  journal={American journal of epidemiology},
  year={2006},
  volume={164 7},
  pages={609-14}
}
Accumulated evidence from searching for candidate gene-disease associations of complex diseases can offer some insights as the field moves toward discovery-oriented approaches with massive genome-wide testing. Meta-analyses of 50 non-human lymphocyte antigen gene-disease associations with documented overall statistical significance (752 studies) show summary odds ratios with a median of 1.43 (interquartile range, 1.28-1.65). Many different biases may operate in this field, for both single… CONTINUE READING

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