Implications of protein flexibility for drug discovery

@article{Teague2003ImplicationsOP,
  title={Implications of protein flexibility for drug discovery},
  author={Simon J. Teague},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={527-541}
}
Proteins are in constant motion between different conformational states with similar energies. This has often been ignored in drug design. However, protein flexibility is fundamental to understanding the ways in which drugs exert biological effects, their binding-site location, binding orientation, binding kinetics, metabolism and transport. Protein flexibility allows increased affinity to be achieved between a drug and its target. This is crucial, because the lipophilicity and number of polar… CONTINUE READING

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