Implications of local angiotensin production in cardiovascular physiology and pharmacology.

@article{Dzau1987ImplicationsOL,
  title={Implications of local angiotensin production in cardiovascular physiology and pharmacology.},
  author={Victor J. Dzau},
  journal={The American journal of cardiology},
  year={1987},
  volume={59 2},
  pages={59A-65A}
}
The traditional concept of the renin-angiotensin system is a circulation-borne endocrine system whose components are secreted by different organs, i.e., renin from the kidney, angiotensinogen from the liver and angiotensin-converting enzyme from the lung. The product of the biochemical cascade, angiotensin II, acts on specific receptors on multiple target organs. Recent data, however, demonstrate that renin and angiotensin are synthesized locally in many tissues. The emerging concept--that… CONTINUE READING
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