Implications of laboratory diagnosis on brucellosis therapy

@article{AlDahouk2011ImplicationsOL,
  title={Implications of laboratory diagnosis on brucellosis therapy},
  author={Sascha Al Dahouk and Karsten Nöckler},
  journal={Expert Review of Anti-infective Therapy},
  year={2011},
  volume={9},
  pages={833 - 845}
}
Brucellosis is a worldwide zoonosis with a huge economic impact on animal husbandry and public health. The diagnosis of human brucellosis can be protracted because the disease primarily presents as fever of unknown origin with unspecific clinical signs and symptoms. The isolation rate of the fastidious etiologic agent from blood cultures is low, and therefore laboratory diagnosis is mainly based on serologic and molecular testing. However, seronegative brucellosis patients have been described… 
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135 Citations
Highly Influential Citations
10
Background Citations
44
Methods Citations
14
Results Citations
1

135 Citations

New developments in the diagnostic procedures for zoonotic brucellosis in humans.
TLDR
The latest microbiological methods for the diagnosis of human brucellosis are reviewed and developments for the future are outlined.
Molecular Diagnosis of Acute and Chronic Brucellosis in Humans
TLDR
PCR-based methods represent applicable and very efficient methods for the diagnosis of acute brucellosis at the earlier time of disease, exploring predictive biomarkers for the post-treatment control as well as for monitoring the course of the disease evolution for the early recognition of relapses.
Laboratory Diagnosis of Human Brucellosis
TLDR
Serological tests will remain the primary tools for the diagnosis and posttherapeutic follow-up of human brucellosis as long as there are no sufficiently validated commercial tests or studies that demonstrate an adequate interlaboratory reproducibility of the different homemade PCR assays, cultures and serological methods.
Microbiological Laboratory Diagnosis of Human Brucellosis: An Overview
TLDR
The most common and updated microbiological diagnostic methods currently available for the laboratory diagnosis of brucellosis are reviewed and reported.
An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies
TLDR
In this review, the recent literature, significant advancements, and challenges in the treatment and vaccination against brucellosis are summarized, with a special focus on developing countries.
Immunodetection of bacteria causing brucellosis
The first report of Brucella suis biovar 1 isolation in human in Turkey.
Isolation of Brucella melitensis from Breast Tissue: A Case Report
TLDR
A case of 51 years old female with brucellosis manifests as breast involvement, which resulted in clinical cure with combination of doxycycline and rifampicin for a duration of eight months and a molecular method such as PCR might be helpful in differential diagnosis.
Brucellosis: It is not only Malta!
TLDR
Molecular typing schemes based on the use of multiple locus variable number of tandem repeats analysis (MLVA) have proven to be able to differentiate unrelated Brucella isolates which could not be differentiated by classical microbiological methods.
Clinical and serological approach to patients with brucellosis: A common diagnostic dilemma and a worldwide perspective.
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TLDR
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