Implications of heparan sulfate and heparanase in neuroinflammation.

  title={Implications of heparan sulfate and heparanase in neuroinflammation.},
  author={Xiao Zhang and Bo Wang and Jin-Ping Li},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
Heparan sulfate proteoglycans (HSPGs), expressed on the cell surface and in the extracellular matrix of most animal tissues, have essential functions in development and homeostasis, and have been implicated in several pathological conditions. The functions of HSPGs are mainly mediated through interactions of the heparan sulfate (HS) polysaccharide side chains with different protein ligands. The molecular structure of HS is highly diverse, expressed in a cell-type specific manner. The flexible… CONTINUE READING
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