Implications of gender and pregnancy for antiretroviral drug dosing.

  title={Implications of gender and pregnancy for antiretroviral drug dosing.},
  author={Brookie Manning Dugan Best and Edmund Capparelli},
  journal={Current opinion in HIV and AIDS},
  volume={3 3},
PURPOSE OF REVIEW This review briefly outlines the influences of gender and pregnancy on drug disposition, and describes the available antiretroviral pharmacokinetic data and dosing recommendations in these groups. RECENT FINDINGS Recent studies in pregnant women continue to document altered exposure of different classes of drugs during pregnancy. While new information shows that tenofovir exposure is significantly decreased during pregnancy, the magnitude of the decrease will not likely… CONTINUE READING