Implications of epidermal growth factor (EGF) induced egf receptor aggregation.

  title={Implications of epidermal growth factor (EGF) induced egf receptor aggregation.},
  author={Carla Wofsy and Byron Goldstein and Karen Lund and H. Steven Wiley},
  journal={Biophysical journal},
  volume={63 1},
To investigate the role of receptor aggregation in EGF binding, we construct a mathematical model describing receptor dimerization (and higher levels of aggregation) that permits an analysis of the influence of receptor aggregation on ligand binding. We answer two questions: (a) Can Scatchard plots of EGF binding data be analyzed productively in terms of two noninteracting receptor populations with different affinities if EGF induced receptor aggregation occurs? No. If two affinities… CONTINUE READING

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