Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy.

@article{Hattiangady2008ImplicationsOD,
  title={Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy.},
  author={Bharathi Hattiangady and Ashok K Shetty},
  journal={Epilepsia},
  year={2008},
  volume={49 Suppl 5},
  pages={26-41}
}
Temporal lobe epilepsy (TLE), characterized by spontaneous recurrent motor seizures (SRMS), learning and memory impairments, and depression, is associated with neurodegeneration, abnormal reorganization of the circuitry, and loss of functional inhibition in the hippocampal and extrahippocampal regions. Over the last decade, abnormal neurogenesis in the dentate gyrus (DG) has emerged as another hallmark of TLE. Increased DG neurogenesis and recruitment of newly born neurons into the… CONTINUE READING