Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity.

@article{Morrison2009ImplicationsOC,
  title={Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity.},
  author={Christopher D Morrison and Peter Raymond Huypens and Laura Ken Stewart and Thomas W Gettys},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1792 5},
  pages={409-16}
}
Insulin and leptin play complementary roles in regulating the consumption, uptake, oxidation and storage of nutrients. Chronic consumption of diets that contain a high proportion of calories from saturated fat induces a progressive deterioration in function of both hormones. Certain rat lines and strains of mice are particularly sensitive to the obesogenic… CONTINUE READING