Implications of autophagy for vascular smooth muscle cell function and plasticity.

  title={Implications of autophagy for vascular smooth muscle cell function and plasticity.},
  author={Joshua K. Salabei and Bradford G. Hill},
  journal={Free radical biology & medicine},
Vascular smooth muscle cells (VSMCs) are fundamental in regulating blood pressure and distributing oxygen and nutrients to peripheral tissues. They also possess remarkable plasticity, with the capacity to switch to synthetic, macrophage-like, or osteochondrogenic phenotypes when cued by external stimuli. In arterial diseases such as atherosclerosis and restenosis, this plasticity seems to be critical and, depending on the disease context, can be deleterious or beneficial. Therefore… CONTINUE READING

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