Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases

  title={Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases},
  author={Kepeng Wang and Sergei I Grivennikov and Michael Karin},
  journal={Annals of the Rheumatic Diseases},
  pages={ii100 - ii103}
Up to 20% of all cancers have been linked to chronic inflammation and persistent infections. However, almost all solid tumours contain immune infiltrates, and tumour-associated inflammatory cells play broad roles in different stages of tumour development and malignant progression. Cytokines are important mediators of the inflammatory effect on tumorigenesis both in inflammation-induced cancer and in the inflammation that follows tumour development. We have shown interleukin (IL)-6 to be an… 
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  • G. Cui
  • Biology
    Front. Oncol.
  • 2019
A review summarizes recent findings and currently available data for understanding the vital role and therapeutic significance of TH9/IL-9, TH17/il-17, and TH22/ IL-22 in the development of colorectal tumorigenesis.


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