Implications of GABAergic Neurotransmission in Alzheimer’s Disease

  title={Implications of GABAergic Neurotransmission in Alzheimer’s Disease},
  author={Yanfang Li and Hao Sun and Zhicai Chen and Huaxi Xu and Guojun Bu and Hui Zheng},
  booktitle={Front. Aging Neurosci.},
Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper-phosphorylated tau. Regardless of the pathological hallmarks, synaptic dysfunction is widely accepted as a causal event in AD. Of the two major types of synapses in the central nervous system (CNS): glutamatergic and GABAergic, which provide excitatory and inhibitory outputs respectively, abundant data implicate an… CONTINUE READING
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