Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.

@article{Vance2002ImplicationsOC,
  title={Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.},
  author={Russell E Vance and Amanda M Jamieson and Dragana Cado and David H Raulet},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 2},
  pages={868-73}
}
Natural killer (NK) cells are believed to achieve self-tolerance through the expression of self-MHC-specific inhibitory receptors, such as members of the Ly49 and CD94/NKG2 families. Individual Ly49 genes are stochastically expressed by NK subsets and are expressed in a monoallelic fashion, but little is known about the mechanisms underlying CD94/NKG2A expression. We show here that, like Ly49 genes, mouse Nkg2a is stochastically and monoallelically expressed. Thus, a single general mechanism… CONTINUE READING

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