Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278).

@article{Kelly2006ImplicationsFV,
  title={Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278).},
  author={Brian N. Kelly and Bruce Richard Howard and Hui Wang and Howard Robinson and Wesley I. Sundquist and Christopher P Hill},
  journal={Biochemistry},
  year={2006},
  volume={45 38},
  pages={11257-66}
}
Gag, the major structural protein of retroviruses such as HIV-1, comprises a series of domains connected by flexible linkers. These domains drive viral assembly by mediating multiple interactions between adjacent Gag molecules and by binding to viral genomic RNA and host cell membranes. Upon viral budding, Gag is processed by the viral protease to liberate… CONTINUE READING