Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource.

@article{Kleinau2007ImplicationsFM,
  title={Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource.},
  author={Gunnar Kleinau and Mara Brehm and Urs Wiedemann and Dirk Labudde and Ulf Leser and Gerd Krause},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 2},
  pages={
          574-80
        }
}
Comparison between wild-type and mutated glycoprotein hormone receptors (GPHRs), TSH receptor, FSH receptor, and LH-chorionic gonadotropin receptor is established to identify determinants involved in molecular activation mechanism. The basic aims of the current work are 1) the discrimination of receptor phenotypes according to the differences between activity states they represent, 2) the assignment of classified phenotypes to three-dimensional structural positions to reveal 3) functional… CONTINUE READING

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